Paediatric Neurodevelopment.

Maternal Cocaine Use.

Non - Neuro Issues

1. Withdrawal 
2. Low birth weight, small size, small HC.
3. Prem births. 
    -  These last 2 features probably related to vasoactive effects on placenta. 
4. Not thought to be majorly teratogenic

Neuro Issues.

1. Developmental cognitive Issues and Delay.
2. Some behavioural issues. 
3. MRI changes are subtle: 
1. Smaller brain volume especially in:  
    1. Cortical grey Matter
    2. Thalamus 
    3. Putamen 
2. In adolescents: Smaller volume pre-frontal cortex & smaller thalami.

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