Puberty Abnormalities
Precocious Puberty (PP)
Definition and Diagnosis
- Girls >= 8ys
- Menarche usually at end.
- Thelarche.
- Boys >= ??
Pathway 1
Findings 1
Central PP
Females: 90% idiopathic. Investigate if very young.
Males: <10% idiopathic. Investigate all.
Causes
| General | Specific | Notes |
|---|---|---|
| A) TUMOURS | ||
| Optic & Hypothalamic Gliomas. | inc Astrocytomas. | |
| Optic & Hypothalamic Ependymomas. | ||
| Pineal Tumours. | ||
| Hamartomas of Tuber cinerum. | often in very young and 'gelastic epilepsy' | |
| Craniopharyngiomas | Rare cause! | |
| B) CONGENITAL | ||
| Neurofibromatosis. | ||
| C) TRAUMA & IATROGENIC | ||
| Hydrocephalus | ||
| Head Injury | ||
| Meningitis & Encephalitis. | ||
| Surgery. | ||
| Radiotherapy. | But HIGH dose assocd with delay. | |
| D) IDIOPATHIC |